Pre-Meeting Symposia

Add a Pre-Meeting Symposia to Your 2025 ASBMR Annual Meeting Expreince

The 2025 ASBMR Symposium and the ASBMR/RBDA 2025 Symposium will be held on Thursday, September 4, 2025, one day prior the 2025 Annual Meeting, at the Seattle Convention Center in Seattle, Washington, USA. Learn more about the goals of each meeting and view the full program.

2025 ASBMR Symposium on Musculoskeletal Impact of Immune and Skeletal Cells Crosstalk: Bench to Bedside

2025 ASBMR/RBDA Symposium on Rare Bone Diseases: From the Genome to the Lived Experience

Organized by Laura Calvi, M.D. and Natalie Sims, Ph.D., the goal of the 2025 ASBMR Symposium on Musculoskeletal Impact of Immune and Skeletal Cells Crosstalk: Bench to Bedside is to to discuss novel interactions between immune cell populations and skeletal cells that impact musculoskeletal health, including pathogenesis of rheumatologic, infectious and age-associated disorders, in order to envision future therapeutic, analytical and diagnostic tools.

Session 1: Reciprocal Interactions of Skeletal and Immune Cells
Session 2: Musculoskeletal Impact of Immune Cells
Session 3: Pathogenesis of Cancer and Age-associated Disorders
Session 4: Future Therapeutic, Analytical and Diagnostic Tools

Session 1: Reciprocal Interactions of Skeletal and Immune Cells
Thursday, September 4, 2025
8:00 am - 8:30 am	Continental Breakfast
8:30 am - 8:45 am	Introduction and Overview	Laura Calvi and Natalie Sims
8:45 am - 9:10 am	Neutrophils/Oncostatin M	Natalie Sims
9:10 am - 9:35 am	Reciprocal suppression between TGFβ signaling and TNF stimulation finetunes the macrophage inflammatory response	Baohong Zhao
9:35 am - 10:00 am	Osteolineage cell efferocytosis links skeletal and hematopoietic homeostasis	Laura Calvi
10:00 am - 10:15 am	Talk from submitted abstracts
10:15 am - 10:30 am	Break
Session 2: Musculoskeletal Impact of Immune Cells
10:30 am - 10:55 am	TBD
10:55 am - 11:20 am	Role of a tubular lysosomal network in osteoclast function	Nathan Pavlos
11:20 am - 11:45 am	TNF- induced activation of Schnurri 3 in osteoblasts contributes to systemic and articular bone loss by suppressing bone formation and enhancing osteoclast development	Jae-Hyuck Shim
11:45 am - 12:00 pm	Talk from submitted abstracts
12:00 pm - 1:00 pm	Lunch and poster viewing
Session 3: Pathogenesis of Cancer and Age-Associated Disorders
1:00 pm - 1:25 pm	DKK1 creates a tumor-supporting environment through the suppression of NK cells during breast cancer progression	Roberta Faccio
1:25 pm - 1:50 pm	Neutrophil anti-tumor responses against bone metastatic prostate cancer: mechanisms and therapeutic opportunities	Leah Cook
1:50 pm - 2:15 pm	Clonal hematopoiesis and its impact on the aging osteo-hematopoietic (CHIP, MDS and its implication on bone health)	Lorenz Hofbauer
2:15 pm - 2:30 pm	Talk from submitted abstracts
2:30 pm - 3:00 pm	Break
Session 4: Future Therapeutic, Analytical and Diagnostic Tools
3:00 pm - 3:25 pm	Acod1 and itaconate are crucial regulators of osteoclast differentiation and bone loss in inflammatory arthritis	Aline Bozec
3:25 pm - 3:50 pm	Role of regulatory T cells in fracture repair	TBD
3:50 pm - 4:15 pm	Translation opportunities in osteomyelitis	Edward Schwarz
4:15 pm - 4:30 pm	Talk from submitted abstracts
4:30 pm - 6:00 pm	Combined Pre-Meeting Symposia reception and poster viewing

Organized by Leanne Ward, Ph.D. and Erik Imel, M.D., with guidance from Outi Makitie, Lynda Bonewald, Wolfgang Hogler, and Chelsey Grimbly, the goal of the 2025 ASBMR/RBDA Symposium on Rare Bone Diseases: From the Genome to the Lived Experience is to gather experts in rare bone diseases to promote interactions among basic, translational and clinical researchers and discuss the latest advances on skeletal dysplasias, disorders of ectopic mineralization, prevention of muscle and bone loss and the diagnosis and treatment of rare bone diseases.

Session 1: Skeletal Dysplasias
Session 2: Disorders of Ectopic Mineralization
Session 3: Prevention of Muscle and Bone Loss
Session 4: From the Genome to the Lived Experience

Session 1: Skeletal Dysplasis
Thursday, September 4, 2025
7:30 am - 8:00 am	Continental Breakfast
8:00 am - 8:15 am	Introduction and Overview	Leanne Ward and Erik Imel
8:15 am - 8:40 am	Osteoclast-Osteoblast Feedback in Fibrous Dysplasia: Insights from Bench and Bedside	Luis de Castro
8:40 am - 9:05 am	Novel Treatment Approaches in Fibrous Dysplasia	Alison Boyce
9:05 am - 9:30 am	New, Disruptive Precision Therapies for Achondroplasia: Changing the Rules of the Game	Ravi Savarirayan
9:30 am - 9:45 am	Talk from submitted abstracts
9:45 am - 10:00 am	Break
Session 2: Disorders of Ectopic Mineralization
10:00 am - 10:25 am	Overview of the Pathophysiology of ENPP1 Deficiency	David Weber
10:25 am - 10:50 am	Hyperphosphatemic Familial Tumoral Calcinosis: Defining Mechanisms to Inform Treatment	Kelly Roszko
10:50 am - 11:15 am	Emerging Therapies for Fibrodysplasia Ossificans Progressive	Edward Hsiao
11:15 am - 11:40 am	XLH and Enthesopathy	Eva Liu
11:40 am - 11:55 am	Talk from submitted abstracts
12:00 pm - 1:00 pm	Lunch and poster viewing
Session 3: Prevention of Muscle and Bone Loss
1:00 pm - 1:25 pm	Mechanisms of Carpo-Tarsal Osteolysis from Pre-Clinical Models	Roland Baron
1:25 pm - 1:50 pm	Clinical studies of vamorolone: An anti-inflammatory corticosteroid with unique structure/activity relationships: not metabolized by HSD11B's, and a MR antagonist	Erik Hoffman
1:50 pm - 2:15 pm	Navigating Advocacy for Individuals with Duchenne Muscular Dystrophy in an Ever-Broadening Therapeutic Landscape	Pat Furlong
2:15 pm - 2:30 pm	Talk from submitted abstracts
2:30 pm - 3:00 pm	Break
Session 4: From the Genome to the Lived Experience
3:00 pm - 3:25 pm	Anti-Sclerostin Antibody for the Treatment of Osteogenesis Imperfecta	Ken Kozloff
3:25 pm - 3:50 pm	Expanding Molecular Diagnoses in Rare Bone Disorders	Frank Rauch
3:50 pm - 4:15 pm	Achondroplasia	Colleen Gioffreda
4:15 pm - 4:30 pm	Talk from submitted abstracts
4:30 pm - 6:00 pm	Combined Pre-Meeting Symposia reception and poster viewing